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Description
Digoxin does not exert its therapeutic and toxic effects until it redistributes from the serum into the myocardium

However, in instances where the inflammatory response remains uncontrolled, these cells undergo a transition in their secretion profile, releasing pro-inflammatory mediators such as interleukin 1, interleukin 6, tumor necrosis factor, acute-phase proteins, and reactive oxygen species
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In addition, the ROS level and glycolysis were assessed via transfection with shGSTM3 and GSTM3-OE

The reclassification to Category 2 may serve as a catalyst for pharmaceutical companies and research institutions to invest in the rigorous clinical trials required for formal FDA approval
