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Screening was performed by the authors with an emphasis on translational relevance to orthopaedic surgery and perioperative decision-making

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0.16 ng/ml/12 ml/day till the sacrifice) and intragastrically after cuprizone instilations, while controls received simultaneously drinking water only (12 ml/day) as well as an equivolume of saline (5 ml/kg) intragastrically after cuprizone instillations

By working at the mitochondrial level, this protocol aims to improve how cells generate energy, repair DNA, and maintain long-term resilience