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Cytokines such as TNF-, IL-6, and IL-1 upregulate NADPH oxidases in reproductive tissues, perpetuating ROS production (121)
doi: 10.1016/j.molmed.2015.02.002 41
These cytokines are produced by adipose tissue macrophages in proportion to the amount of visceral fat
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The main cause of oxidative stress is an increased production or accumulation of ROS and RNS, a known class of highly reactive compounds containing oxygen and nitrogen respectively
