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J Biol Chem 249(22):71307139 Hagrman D, Goodisman J, Souid AK (2004) Kinetic study on the reactions of platinum drugs with glutathione

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Increased d-lactic acid theory Another theory regarding the reduced intestinal pH and increased gut permeability in ME/CFS patients is the increased production of D-lactic acid due to the overgrowth of Gram-positive bacteria such as Enterococci and Streptococci, which leads to systemic inflammation, immune activation, and oxidative stress [22, 44]