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Furthermore, the agonists of Nrf2, which serve as pivotal upstream regulators of SLC7A11, function as indirect activators of System Xc-, as they regulate SLC7A11 at the transcriptional level rather than directly modifying the functional activity of the complex (139)

The increased ROS level impacts the integrity of the RBC membrane, which impacts the red blood cell (RBC) function, leading to impaired hemostasis and thrombosis

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Patients often notice sleep onset, sleep depth, or sleep continuity changes within two to four weeks of completing the loading cycle

The formation of a focal adhesion starts when integrins on the cell membrane bind to the ECM