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Clinicians are unprepared, which is why health systems need to prioritise training, early identification, and finding a better way to reduce harm in young people, he said

J Clin Endocrinol Metab (2020) 105:e3241

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If genuine tachyphylaxis is confirmed, strategies include dose escalation to the next tier, brief treatment breaks of 2 to 4 weeks to allow receptor resensitization, or switching to alternative GLP-1 agonists like semaglutide to provide different receptor activation patterns

These components strengthen the skin's immunity, making it less reactive, improving barrier functions