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Oxidative stress is linked to mitochondrial DNA (mtDNA) damage, and it was found that the genes in mitochondrial complex I of oxidative phosphorylation are downregulated in the brain tissue of AD patients (Marmolejo-Garza et al., 2022)

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Sadly they did not specifically select publications which gave treatment at the correct time but they did conclude that DSPS was an area where melatonin could be useful

Nonetheless, this salinity escape of GLSs is attenuated by raising the Sal- level (80 mM)

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