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Oxidative stress is linked to mitochondrial DNA (mtDNA) damage, and it was found that the genes in mitochondrial complex I of oxidative phosphorylation are downregulated in the brain tissue of AD patients (Marmolejo-Garza et al., 2022)

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Sadly they did not specifically select publications which gave treatment at the correct time but they did conclude that DSPS was an area where melatonin could be useful

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Nonetheless, this salinity escape of GLSs is attenuated by raising the Sal- level (80 mM)

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