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It has been proposed that the PI Z variant may aggregate into polymers that precipitate and accumulate in cutaneous soft tissues, leading to inflammation and necrotizing skin lesions ( A1AT is the most abundant serum serine protease inhibitor with anti-protease property ( Figure 1 ) ( Figure 1 Data on the safety of A1AT replacement therapy remain limited due to the rarity of the underlying condition, which currently has only one approved indication for treatment

The real question isn't whether NAC works, but whether you'd rather wait for your body to convert NAC into glutathione, or deliver glutathione directly where it's needed most

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162 YinX.ZhangX.LvC.LiC.YuY.WangX.et al (2015)

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