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Other examples of a biochemical role of ROS are found in primitive organisms, where ROS are involved in the cross-linking of the extracellular matrix [4] and in the hardening of the fertilisation envelope after egg-sperm fusion [5]

The consumption of dietary materials with gut barrier promoting properties also represents a useful and cost-effective strategy to reduce the risk of inflammatory disease development

Doherty et al, 2014

Neuronal loss can exacerbate the seizure severity (Zhang et al., 2002), and crucially, neuronal damage is directly associated with the initiation of epilepsy (Sayin et al., 2003)