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However, with twist angles of about 5 for L peptides versus 10 for DRI peptides is the difference still small, see Table 2

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The method of embodiment1, wherein the drug-induced ototoxicity is hearing loss

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DISCUSSION The goal of this study was to develop an AngIV-derived molecule that retained the procognitive/antidementia activity of AngIV and Nle 1 -AngIV but possessed improved pharmacokinetic properties, thus allowing it to penetrate the BBB in sufficient quantities to reach therapeutic levels in the brain