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Blaevi I, Montaut S, Burul F, Rollin P

Various clinical and in vivo studies have been undertaken to evaluate the effects of foods and food-derived components on the activity of detoxification pathways, including phase I cytochrome P450 enzymes, phase II conjugation enzymes, Nrf2 signaling, and metallothionein

It has been suggested that indole ring of melatonin undergoes the addition of free radical or donation of electron to neutralize the free radicals.44,45 Melatonin has been found to directly scavenge variety of free radicals such as O, OH, ONOO and H2O2.46 Overall oxidative stress, in aerobes, is initiated with the reduction of molecular or ground state oxygen into superoxide anion (O2) free radical which further interact and transform into more toxic free radicals such as OH, ONOO and H2O2

10.1093/hmg/8.11.2107 [DOI] [PubMed] [Google Scholar] Petris MJ, Mercer JF, Culvenor JG, Lockhart P, Gleeson PA, & Camakaris J (1996)

Side effects that greatly impact daily function or quality of life should be assessed even if not immediately dangerous
