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COMT SNPs, inadequate nutrient cofactors, or a sluggish liver can slow this process, contributing to higher levels of circulating estrogen

Serum BDNF levels were lower in patients with AD and moderate cognitive dysfunction than in standard controls, according to casecontrol research involving 23 patients with AD, 22 patients having moderate cognitive dysfunction, and 21 standard controls (, 2021)

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The fact that NRF2 is readily inducible in cultured astrocytes suggests that most pharmacological NRF2 activators may specifically target astrocytes in vivo, although there is still limited direct evidence for this

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