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Wang B, Zhu S, Guo M, Ma RD, Tang YL, Nie YX, et al

It was evidenced by the activation of Wnt and NF-B signaling transduction and the expression of differentiation markers [COL1A, alkaline phosphatase, osteocalcin (OCN), core-binding factor alpha 1, and osteoprotegerin

Interstitial delivery Drug delivery through intrathecal and intracerebroventricular strategies elude the BBB to some point, the direct administration of therapeutic drugs into the interstitium is the most direct strategy of brain targeting delivery systems [168]

Some transcription factors regulate ferroptosis-related genes in response to oxidative stress, for example, p53 decreases cystine uptake by inhibiting the expression of Solute carrier family 7 member 11 (SLC7A11), one of the components of the Xc system, thereby increasing cellular susceptibility to ferroptosis [122]

[5] That said, as with any bioactive compound used off-label, individual responses vary and medical oversight is important