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Increased infiltration and activation of mast cells [162,163,164,165], together with elevated levels of mast cell mediators, including histamine and proteases, but also relevant miRNAs and neurotrophins have been substantiated in DGBIs [166,167,168,169]

For example, cystatin C is suitable for the detection of renal impairment in patients with GFRs in the creatinine-blind range, and it is not significantly influenced by muscle mass, age, or ethnicity (117)

Since the introduction of hybridoma technology in 1975, the field has been advanced by a succession of innovations including chimeric and humanized antibody engineering, phage display, transgenic mouse platforms and high-throughput single B cell isolation

Dringen, R., et al., Glutathione-Dependent Detoxification Processes in Astrocytes

95% CI, 1.38-5.49