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Often preferred when neurological symptoms are prominent

Franjic, S

Epigenetic effects include modulation of chromatin structure and DNA methylation, promoting access to beneficial genes while repressing harmful ones

Since MTHFR deficiency is one of the treatable metabolic disorders not identified by current newborn mass screening, we should consider the possibility of MTHFR deficiency in adolescents with mental retardation who display abnormally elevated homocysteine in association with progressive neurological or psychiatric dysfunction and leukoencephalopathy

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