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However, contradictory findings were obtained in a recent study which concluded that mutant TDP-43 A315T does not impair mitochondrial bioenergetics in vitro and in vivo (Kawamata et al., 2017)

While many studies show that chronic (several day) exposure during development induces morphological, behavioral, and genomic changes, very few have examined the effect of a brief exposure and/or the impact of a recovery/washout period on assessed outcomes

Nitric oxide NO - biogeneration regulation and relevence to human diseases

This leads to the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum lumen, initiating the endoplasmic reticulum stress response and triggering the unfolded protein response (UPR) (Oakes and Papa, 2015)

Immunometabolism 3 , e210003 (2021)