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One of the investigations reported that NPs were loaded with nuclear factor kappa B (NF-B) inhibitors, a key regulator of inflammation, which could suppress the microglial activation and decrease the production of pro-inflammatory cytokines
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Such compounds are able to inhibit SystemX c , thus leading to exhaustion of cysteine in cells, GPX4 inactivation, accumulated lipid peroxides, and eventually ferroptotic cell death
The analysis was performed on a C18 column (YMC-Pack Pro C18, 250 X 4.6, S-5 m, 12 nm) under reversed-phase partition chromatographic conditions
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