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Conversely, blocking the ICOS ligand preserves and enhances the memory-like phenotype of exhausted precursor T cells, thereby improving tumor control and synergizing with PD-1/PD-L1 blockade [359]

3rd, Lafaille, J

There is evidence that folic acid could be absorbed and utilized by humans within a tolerable upper intake level (1000 g/day), and DHFR has sufficient capacity in humans to efficiently metabolize normal doses of folic acid [42,43,44,45]

doi: 10.1007/s00702-011-0750-2

Lancet 346:547552 Villalobos V, Hernndez-Fonseca JP, Bonilla E, Medina-Leendertz S, Mora M, Mosquera J (2015) Ultrastructural changes of caudate nucleus in mice chronically treated with manganese