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From a hematology perspective, Vitamin B12 plays a crucial role in red blood cell production and the prevention of hematological disorders such as megaloblastic anemia

The LAT subunits are members of the amino acid polyamine cation (APC) superfamily 32 , which exhibit a conserved 5 + 5 inverted topology fold, wherein the first five TM helices are related to the second five helices via a pseudo two-fold symmetry axis running parallel to the plane of the membrane 33

This is the mechanism behind Pernicious Anaemia and can also result from ageing or Helicobacter pylori infection