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In certain cases, when symptoms are unusual or to follow-up on abnormal results from the history, exam, and labs, more complex diagnostic tests may be called for, including additional lab work, brain imaging, and others

TP53 aberrations are among the reported genetic events and important markers of poor prognosis in MM [476]

Furthermore, current interventions predominantly rely on one-size-fits-all formulations, neglecting individual variability among patients with DGE

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