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Loss of Unc5B decreases BBB Wnt/catenin signaling, and -catenin overexpression rescues Unc5B mutant BBB defects

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A method of preventing gait abnormalities in a patient with Parkinson's disease or of improving or restoring to normal the gait of a patient with Parkinson's disease, comprising the step of administering to said patient an amount of one or more hepatocyte growth factor mimics sufficient to prevent, improve or restore to normal said gait, said one or more hepatocyte growth factor mimics having a general structural formula 1 2 3 where Ri is one of an N-acyl group, a substituted or unsubstituted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s-benzyl cysteine

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The endothelial BBB is localized in all the layers of cerebrospinal tree, whereas the epithelial blood-CSF is positioned in the brain ventricular system [5]