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Placing sipes in a block increases flexibility that can reduce noise levels, says Richards, but the slits create smaller blocks that provide additional sound-generating sources at higher frequencies. Kenny says tread designers intentionally vary the depth of sipes for noise control

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10.1111/j.1369-1600.2012.00476.x 238 SingletonE

Membrane-active amphipathic peptide WRL3 with in vitro antibiofilm capability and in vivo efficacy in treating methicillin-resistant Staphylococcus aureus burn wound infections