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The phenomenon where repeated peptide exposure reduces response magnitude
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Such a low incidence of abscopal effects may be due to the increased intratumoral release of immunosuppressive cytokines such as TGFb and CCL2 by IR (Mondini et al, 2020

doi: 10.1016/j.psyneuen.2010.03.010

Further research into AMLs metabolic plasticity and precision medicine approaches is crucial for improving treatment outcomes
