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The cancer connection is currently theoretical but plausible given these biological effects
Patients suffering from type I, also called congenital familial nonhemolytic jaundice with kernicterus, completely lack the UGT1A1 enzymatic activity resulting in toxic effects of bilirubin on the central nervous system
Sleep interruption associated with house staff work schedules alters circadian gene expression

[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Mattson M.P., Longo V.D., Harvie M

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