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[54] N-acetylcysteine was found to reduce melasma in a double-blind, placebo-controlled study on 12 female patients who were prescribed a combination of 4.7% n-acetylcysteine and 2% hydroquinone

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However, Muramatsu et al

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This is particularly important in the context of inflammation, where mast cells can rapidly regain high levels of labile zinc after degranulation [187]