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The exploratory efficacy measurements, including Symptoms Of Depression Questionnaire (SDQ), Montgomery-Asberg Depression Scale (MADRS), Clinical Global ImpressionsImprovement (CGI-I), and The Massachusetts General Hospital (MGH) Cognitive and Physical Functioning Questionnaire (CPFQ) showed a promising reduction in depressive and cognitive symptoms across all measures for NSI-189, with significant improvement in the SDQ and CPFQ, and a medium to large effect size for all measures

Minoxidil (8%): Opens ATP-sensitive potassium channels (KATP) in vascular smooth muscle and hair follicle cells, causing vasodilation, increased scalp microcirculation, and direct follicular cell stimulation

Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

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Limitations include reliance on animal models (e.g., germ-free mice) that do not fully mimic human physiology, small human cohorts, and variable sequencing methods leading to non-reproducible taxa changes