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A consistently dark or unusual color could be a sign of a kidney issue, such as urine color and kidney disease, and should be evaluated by a medical professional

2022. Systems approach to NAD+ restoration via NNMT inhibition

Potential kidney protection with liraglutide and semaglutide: Exploratory mediation analysis
The area postrema downregulates amylin receptor density in response to sustained agonism, which is how nausea resolves over time

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