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In addition, autocrine cytokines secreted by tumor-induced monocytes further amplify the expression of the transcription factors SREBP2 and LXR, enhancing their activation and downstream signaling pathways (81)

During viral infection, increased viral replication leads to a higher viral load causing significant oxidative damage to lung tissue

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Use species-level signals (e.g., DHE-HPLC for O 2 via 2-OH-E, compartment-targeted HyPer/roGFP-Orp for H 2 O 2 , peroxiredoxin redox state as a fast sentinel) to attribute source and location, use footprints (F-isoprostanes, protein carbonyls/nitrotyrosine, 8-oxoG) to gauge exposure, add buffer indices (GSH/GSSG, TAC) and iron axis (labile iron pool, oxidized phospholipids, GPX4 context) to estimate OH/ferroptosis propensity