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Because we know precisely where and how the glucuronide moiety binds (11, 12, 25, 27, 28), and these substrate molecules have a limited number of rotatable bonds, we know with reasonable certainty where these estrogens are within the active site

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FuS-PWangJFXueWJLiuHMLiuBRZengYLet al

Copper is a required cofactor for a family of cuproenzymes, and the availability of copper to those enzymes is a plausible node through which a copper carrier could exert broad influence without a single dedicated receptor

When UDCA is given simultaneously with NaDOC, the intestinal Ca 2+ absorption is similar to that from the control animals, which means that UDCA prevents the inhibition in the Ca 2+ transport caused by NaDOC