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Summary: Cagrilintide and retatrutide are investigational injectable medicines being studied for obesity and type 2 diabetes in men, targeting multiple hormonal pathways to reduce appetite, improve blood glucose control, and increase energy expenditure, but neither is currently licensed in the UK

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FGF also stimulates glial cells (Mller cells) providing trophic support to neurons

Both regimens improved the sleep of subjects, with each arm describing an increase in the number of sleeping hours compared to baseline [23]

Survodutide, with its dual agonism, might offer additional benefits through increased energy expenditure and direct metabolic improvements, making the Cagrilintide vs Survodutide decision a strategic one based on desired mechanistic insights