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So people at greatest risk for deficiency include those with low stomach acid (e.g., older adults and people on proton pump inhibitors or antacids) or low IF production (known as pernicious anemia), people on medications that interfere with B12 absorption (such as metformin), people who have had gastric surgery, those with GI conditions that impair nutrient absorption (like celiac or Crohn's disease), and people on vegan and vegetarian diets

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In addition, -syn and p--syn levels increased in the insoluble fraction of RIPA following hypoxic treatment for 7 days, suggesting that hypoxia promoted the phosphorylation of -syn and long-term hypoxia promoted -syn to form abnormal aggregates in the insoluble fraction (Fig

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Liu W-T, Jing Y-Y, Yu G-F, Chen H, Han Z-P, Yu D-D, Fan Q-M, Ye F, Li R, Gao L, et al
