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Progestins provide a three-dimensional conformation of the genome by stabilising the binding of structural proteins (such as RAD21, YY1, and Mediator), thereby ensuring the stability of chromatin cycling between enhancers and promoters, as well as ensuring the supply of hormones, which allows for increased expression of C/EBP, which consequently reduces the risk of breast cancer

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Some authors recommend anatomopathological examination for diagnostic confirmation, although others sustain that the diagnosis is only clinical and follow-up is necessary to investigate changes in size, shape, and color of the lesion