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Exposure to arsenic (As) leads to an increase in the generation of ROS and raises the levels of heme oxygenase (HMOX1), a crucial modulator of heme oxidation and reaction to stress in kidney epithelial cells (49)

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Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1 in articular chondrocytes: involvement of HIF-1 in the pathogenesis of osteoarthritis

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