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Description
In the N-acetyl form, an acetyl group is added to the N-terminus of the four-residue chain, a modification commonly used in peptide chemistry to alter charge, lipophilicity, and resistance to aminopeptidase activity relative to the unmodified peptide
This is normally considered benign, and patients may not even realize they are carriers
If you're starting methylfolate, the safest approach is starting at a low dose and working with a clinician who can adjust based on how you respond
doi: 10.1002/ana.24088 74 GerhardsRPfefferLKLorenzJStarostLNowackLThalerFSet al
10.1351/PAC-REC-10-12-04 Pure Appl Chem
