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doi: 10.1007/s002170000189

Outcomes vary by person, and the strength of the evidence varies by application, so results should be framed honestly rather than promised

Here, we show that lactate production by patient-derived GSCs and microglia/macrophages induces tumor cell epigenetic reprogramming through histone lactylation, an activating modification that leads to immunosuppressive transcriptional programs and suppression of phagocytosis via transcriptional upregulation of CD47 , a dont eat me signal, in GBM cells

Berg A, Rooyackers O, Norberg A, Wernerman J

Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation