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10 , e2203699 (2023)

In a mouse model of hepatic encephalopathy, reduced expression of neuronal fractalkine, a molecule that promotes off signaling to microglia, resulted in elevated microglia activation, with increased expression of CCL2, IL-6, and TNF- (McMillin et al., 2016), which was also seen in a hepatic injury modeled by a bile duct ligation (Dhanda et al., 2018)

Understanding this distinction is crucial for knowing when to treat at home and when to seek medical guidance for tirzepatide concerns