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Reactive oxygen species (ROS) and free radicals generated during oxidative stress can cause oxidative damage to biomolecules such as lipids, proteins, and DNA, resulting in cellular dysfunction and tissue injury

Access this article Similar content being viewed by others References Monod J, Changeux J-P, Jacob F: Allosteric proteins and cellular control systems

this compound is autocyclized to form 5-OP when there is an insufficient amount of Cys as a substrate, as discussed above in the development of 5-oxoprolinuria

In yeast, 12-hydroxyeicosatetraenoic acid (which is probably a product of GPX4 depletion in mammals) is a substrate for Atg8 (MAP1LC3 [microtubule-associated protein 1 light chain 3] in mammalian cells) lipidation required to activate autophagy [156]