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For example, if you have pernicious anemia, you might need injections for life

In fact, people who have B12 deficiency are at higher risk of megaloblastic anemia, which essentially means the body does not have the ability to make enough red blood cells to carry oxygen through the body and leads to chronic fatigue

5Amino1MQ (5Amino1Methylquinolinium) is a novel small molecule derived from quinolinium salts that has been studied for its ability to inhibit NNMT (Nicotinamide NMethyltransferase), an enzyme involved in metabolic dysfunction, obesity, and cellular aging

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One review concluded that vitamin B12 plays a key role in fat metabolism, noting that a deficiency could be linked to increased fat accumulation and obesity ( Another animal study found that severe vitamin B12 deficiency led to a significant increase in body fat percentage and cholesterol levels in pregnant mice ( Whats more, one animal study showed that administering B vitamins to rats fed a high fat diet reduced weight gain and increased levels of several enzymes that influence metabolism, compared with a control group ( However, current evidence is lacking, and additional high quality studies are needed to determine how vitamin B12 may affect metabolism and body fat in humans