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As superoxide is subject to efficient dismutation by cellular superoxide dismutases, it is possible that NFT might directly interact with Keap1 to induce the observed release of Nrf2 and its escape from proteasomal degradation

The accumulation of transcripts of Alu RNA in geographic AMD was caused due to dysregulation in DICER1

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doi: 10.1016/0041-008X(89)90119-1
