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Description
Here we used three criteria to find variants of interest

Total RNA was extracted from frozen tissues by homogenizing each tissue sample using a battery-operated pestle mixer (Argos Technologies, Vernon Hills, IL) in 1 ml of TRIzol reagent according to the manufacturers protocol (Life Technologies, Carlsbad, CA)

Metabolic decompensation: usually occurs in infants aged 3 to 24 months, manifested by hypoglycemic coma, feeding difficulties, irritability, lethargy, hepatomegaly, elevated liver enzymes, and elevated transaminases

A: It is recommended to store this product at room temperature as per the storage instructions provided

Topical retinoids are recommended as a mainstay treatment during the maintenance phase [6]