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[DOI] [PMC free article] [PubMed] [Google Scholar] Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T, et al

Results RS has been shown to affect sperm growth and function, interfere with cellular signaling, and damage mitochondrial integrity

These findings are relevant to cellular aging research because melatonin intersects with multiple hallmarks of aging it is involved in oxidative stress signaling, inflammatory pathways, and mitochondrial function through both receptor-dependent and receptor-independent mechanisms

MSNs have been designed to overcome it through various approaches: (i) surface modification with BBB-penetrating ligands (transferrin, angiopep-2), (ii) use of receptor-mediated transcytosis, (iii) nasal delivery for nose-to-brain targeting, and (iv) temporary BBB modulation (e.g., targeted ultrasound) in combination with MSN delivery [258,259]

Harding, V