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Due to significant controversial findings in MTHFR mutation and DNA methylation in both healthy populations and psychiatric patients, investigation of MTHFR activity in peripheral samples might be important

doi: 10.1016/j.bjoms.2009.11.009

doi: 10.2174/1567205014666170829101016 51 GwakM

J Endocrinol 147:3341 Corkey BE, Glennon MC, Chen KS, Deeney JT, Matschinsky FM, Prentki M (1989) A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells

These typically resolve within hours to days and diminish with repeated doses
