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Beyond these functions, ATM regulates peroxisome and mitochondrial function 8,9 and impacts glucose import (GLUT1 pS490) and the glycolysis/pentose phosphate pathway (PPP) switch (HSP27:G6PD), particularly in response to exogenous damage 10,11

While these reactive oxygen species (ROS) have essential roles in signaling and host defense, supraphysiological levels of ROS and/or impaired antioxidant defenses may causes oxidative damage to DNA, proteins, and lipids, resulting in mitochondrial dysfunction and even cell death [47]
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It can also be prescribed off-label for weight loss