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Health 32, 117
The balance between GSH and GSSG is commonly used to assess oxidative stress and the overall redox state within cells, tissues, and bodily fluids
Pisitsak P
By operating with GSH as its reducing substrate, GPX4 exhibits remarkable efficacy against diverse lipid peroxidation products, thereby blocking cell death induced by cytoplasmic or mitochondrial ROS and lipid peroxidation [48]
In PD, early GSH depletion in the substantia nigra precedes dopaminergic neuron loss, suggesting that redox dysfunction may be an inciting event that leads to eventual neuronal damage (Smeyne and Smeyne, 2013)
