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[DOI] [PMC free article] [PubMed] [Google Scholar] 701

Tirzepatide (Mounjaro/Zepbound) already delivers 15-22% body weight loss through dual GIP/GLP-1 receptor activation - making it one of the most powerful single-agent options available

Key Takeaways GLP-1 receptor agonists have strong efficacy data but significant GI side effect burden

Clinical Response Evaluation Timeline How well patients respond to vitamin B12 therapy can differ

It plays an important role in regulation of airway blood flow [37], smooth muscle contraction [172], immune cell/mast cell modulation [167, 169] and secretion output from submucosal glands [173, 174]
