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[DOI] [PMC free article] [PubMed] [Google Scholar] 701

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Tirzepatide (Mounjaro/Zepbound) already delivers 15-22% body weight loss through dual GIP/GLP-1 receptor activation - making it one of the most powerful single-agent options available

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Key Takeaways GLP-1 receptor agonists have strong efficacy data but significant GI side effect burden

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Clinical Response Evaluation Timeline How well patients respond to vitamin B12 therapy can differ

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It plays an important role in regulation of airway blood flow [37], smooth muscle contraction [172], immune cell/mast cell modulation [167, 169] and secretion output from submucosal glands [173, 174]

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