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The activated Nrf2-sMaf heterodimer binds to antioxidant response element (ARE) sequences in the promoter of a tandem of antioxidant genes, including heme oxygenase-1 (HMOX1), aldo-keto reductases, glutathione, and glutathione-S-transferase (Tonelli et al., 2018), to trigger their expression

This makes oral administration an interesting choice for those dealing with stress-induced GI dysfunction or inflammatory bowel conditions linked to mood disorders

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