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Macrophage activation by ROS, cytokines and commensal lipopolysaccharide (LPS) results in the activation of NF-B and PI3K/AKT signaling pathways (72, 73)

For analysis of intact cells, HepG2 (10 7 /ml in DMEM medium w/o serum and antibiotics) were treated with NFT (5 mM)

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In addition, intraperitoneal injection of Wistar rats with megadoses of pyridoxine (500 mg/kg or 1,000 mg/kg per day, for 2 to 6 weeks [28]) did not significantly alter the serum levels of testosterone [29]

Additionally, BER prevents the activation of the LRR, NACHT, and PYD domain-containing protein 3 (NLRP3) inflammasome during PD-related inflammation and restores autophagy activity that safeguards dopamine neurons [24]