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Although AAVs present some disadvantages, arising mainly from the use of viruses as carriers, the ongoing research is trying to address and improve these limitations and develop novel and safer formulations (Griesenbach and Alton, Non-viral Vectors Non-viral vectors have the potential to overcome some limitations of viral vectors, due to their easy scale-up processing, safety and stability

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J Biol Chem (2015) 290(48):2890114