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Beyond GPX4s protection against lipid peroxide-mediated death in conditions like lupus nephritis, the transcription factor NRF2 bolsters cellular redox defenses, while in heart failure, renal proximal tubules sustain high ATP demand through a finely-regulated iron cycleinvolving transferrin endocytosis, DMT1 transport, mitochondrial use, ferritin storage, and ferroportin exportto conserve iron and prevent its urinary loss (119)

[DOI] [PMC free article] [PubMed] [Google Scholar] 147.El-Dakdouki M

doi: 10.1111/j.1432-1033.1980.tb04605.x
