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Plateau hypoxia attenuates the metabolic activity of intestinal flora to enhance the bioavailability of nifedipine

Gut Flora, Nutrition, Immunity and Health edited by Roy Fuller, Gabriela Peridign

Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice

doi: 10.1016/j.taap.2004.06.021

Factors that make anticholinergic burden more harmful include: Multiple drugs adding together, even weak ones (e.g., some treatments for urinary incontinence or IBS) Inflammatory stressors such as hospitalisation, frailty, or polypharmacy Long-term use, which increases the cumulative impact Advanced age and frailty, which make people more sensitive Effects being mistaken for normal ageing, leading to under-recognition The potential for a prescribing cascade, where new drugs are added to treat what are actually side effects Because clomipramine is such a strong serotonin reuptake inhibitor, it carries a higher risk of serotonin syndrome than other TCAs (25)